My Medication Isn't Working — What Should I Do?
This article is for general informational purposes only and is not medical advice.
Please consult your primary care physician or your doctor through the Member Portal before making any decisions about your treatment. This content is intended as a general guide only.
Give It Time
Weight loss medications like tirzepatide and semaglutide work gradually. It's normal to not see dramatic results in the first few weeks, especially at a starting dose.
Typical Timeline
| Timeframe | What to Expect |
|---|---|
| Weeks 1–2 | Medication begins working; effects may be subtle |
| Weeks 3–4 | Many patients notice reduced appetite |
| Weeks 4–8 | Measurable weight loss typically begins |
| Months 2–3+ | More significant results as dose is optimized |
Some patients don't notice appetite changes or weight loss until their dose is increased. This is normal and expected.
Common Reasons for Slow Progress
- You're on a starting dose — Starting doses (like 2.5mg) are meant to help your body adjust, not necessarily to cause significant weight loss
- It's too early — Give your current dose at least 4 weeks before evaluating
- Diet and activity — The medication works best combined with a balanced diet and regular movement
- Individual variation — Everyone responds differently; some people need higher doses to see effects
What To Do
1. Talk to Your Doctor
Click Talk to Doctor in the left sidebar of your member portal, select your order, and let your doctor know:
- How long you've been on your current dose
- Whether you've noticed any appetite changes
- Your current weight compared to when you started
- Any side effects
2. Complete Your Check-In
At your scheduled check-in (around week 4–5), your doctor will evaluate your progress and may recommend a dose increase.
3. Track Your Progress
Small changes add up. Track:
- Weekly weight (same day, same time)
- Appetite and hunger levels
- Energy and how you feel overall
When to Be Concerned
Contact your doctor if you:
- Are gaining weight despite following recommendations
- Have been on an optimized dose for 8+ weeks with zero change
- Are experiencing side effects that prevent you from taking the medication
Remember: This is a marathon, not a sprint. Most patients see their best results over 3–6 months as their dose is gradually optimized.